S05E07 - Il Warfarin

Link, immagini e approfondimenti

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Colonna Sonora

• Così parlò Zarathustra, Richard Strauss

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Immagini

Trifoglio dolce (Melilotus officinalis)

Struttura chimica della Cumarina

Struttura chimica del Dicumarolo

Frank Schofield

Karl Link al lavoro nel suo laboratorio

Il Warfarin viene presentato al pubblico come veleno per topi

Dwight Eisenhower in sedia a rotelle dopo l’attacco cardiaco

Una moderna confezione di Warfarin medicinale

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Bibliografia

• Roderick, L. M. The pathology of sweet clover disease in cattle. J. Am. Vet. Med. Assoc. 74, 314–325 (1929)

• Roderick, L. M. A problem in the coagulation of blood: 'sweet clover disease of cattle'. Am. J. Physiol. 96, 413–425 (1931

• Campbell, H. A. et al. Studies on the hemorrhagic sweet clover disease: I. The preparation of hemorrhagic concentrates. J. Biol. Chem. 136, 47–55 (1940)

• Campbell, H. A. et al. Studies on the hemorrhagic sweet clover disease: II. The bioassay of hemorrhagic concentrates by following the prothrombin level in the plasma of rabbit blood. J. Biol. Chem. 138, 1–20 (1941) 

• Campbell, H. A. & Link, K. P. Studies on the hemorrhagic sweet clover disease: IV. The isolation and crystallization of the hemorrhagic agent. J. Biol. Chem. 138, 21–33 (1941)

• Stahmann, M. A. et al. Studies on the hemorrhagic sweet clover disease: V. Identification and synthesis of the hemorrhagic agent. J. Biol. Chem. 138, 513–527 (1941)

• Whitlon, D. S. et al. Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry 17, 1371–1377 (1978)