Mirabilia

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S05E07 - Il Warfarin
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S05E07 - Il Warfarin

Link, immagini e approfondimenti

Podcast Mirabilia
Jan 30
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S05E07 - Il Warfarin
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Colonna Sonora

  • Così parlò Zarathustra, Richard Strauss


Immagini

File:Illustration Melilotus officinalis1.jpg - Wikimedia Commons
Trifoglio dolce (Melilotus officinalis)
Coumarin2.png
Struttura chimica della Cumarina
Dicumarol.svg
Struttura chimica del Dicumarolo
Frank Schofield
Figure thumbnail fx1
Karl Link al lavoro nel suo laboratorio
 Attendees at the 1954 Farm and Home exhibit examine Link’s display showing the effect of warfarin on rats. Photograph by William Wollin. UW–Madison Archives/ID S16314.
Il Warfarin viene presentato al pubblico come veleno per topi
How past U.S. presidents have battled illness in office
Dwight Eisenhower in sedia a rotelle dopo l’attacco cardiaco
Warfarin Tablet M Care Exports | Pharmaceutical Exporters
Una moderna confezione di Warfarin medicinale

Bibliografia

  • Roderick, L. M. The pathology of sweet clover disease in cattle. J. Am. Vet. Med. Assoc. 74, 314–325 (1929)

  • Roderick, L. M. A problem in the coagulation of blood: 'sweet clover disease of cattle'. Am. J. Physiol. 96, 413–425 (1931

  • Campbell, H. A. et al. Studies on the hemorrhagic sweet clover disease: I. The preparation of hemorrhagic concentrates. J. Biol. Chem. 136, 47–55 (1940)

  • Campbell, H. A. et al. Studies on the hemorrhagic sweet clover disease: II. The bioassay of hemorrhagic concentrates by following the prothrombin level in the plasma of rabbit blood. J. Biol. Chem. 138, 1–20 (1941) 

  • Campbell, H. A. & Link, K. P. Studies on the hemorrhagic sweet clover disease: IV. The isolation and crystallization of the hemorrhagic agent. J. Biol. Chem. 138, 21–33 (1941)

  • Stahmann, M. A. et al. Studies on the hemorrhagic sweet clover disease: V. Identification and synthesis of the hemorrhagic agent. J. Biol. Chem. 138, 513–527 (1941)

  • Whitlon, D. S. et al. Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry 17, 1371–1377 (1978)

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